Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease.
Nat Commun 2025
Sheehan Lab
Advancing Sickle Cell Disease Research and Treatment
Our Mission
The Sheehan Lab is dedicated to developing and improving therapies for individuals living with sickle cell disease. Our multifaceted approach combines genomics, clinical research, and innovative biomarker development to better understand and treat this complex disease.
Research Focus
Genomics & Therapy
Identifying genetic factors and new drug targets to increase fetal hemoglobin levels.
Pain Management
Investigating genetic factors in chronic pain development and biomarker research.
Biomarker Development
Creating new methods to evaluate red cell function and therapy effectiveness.
Gene-Based Therapies
Evaluating and improving gene therapy approaches for better patient outcomes.
Latest Publication
Lab Life
Our team working together to advance sickle cell disease research
